Multifaceted Roles of Crystallography in Modern Drug Discovery
The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosome...
| Corporate Author: | |
|---|---|
| Other Authors: | , , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2015.
|
| Series: | NATO Science for Peace and Security Series A: Chemistry and Biology,
|
| Subjects: | |
| Online Access: | Full Text via HEAL-Link |
Table of Contents:
- Preface
- List of Contributors
- Engineering G Protein-Coupled Receptors for Drug Design
- Structural Insights into Activation and Allosteric Modulation of G Protein-Coupled Receptors
- Epigenetic Drug Discovery
- Crystallography and Biopharmaceuticals
- Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors
- Considerations for Structure-Based Drug Design Targeting HIV-1 Reverse Transcriptase.-Protein-Ligand Interactions as the Basis for Drug Action
- The Protein Data Bank: Overview and Tools for Drug Discovery
- Small Molecule Crystal Structures in Drug Discovery
- Protein Aggregation and its Prediction
- Importance of Protonation States for the Binding of Ligands to Pharmaceutical Targets
- Protein-Protein Interactions: Structures and Druggability
- Achieving High Quality Ligand Chemistry in Protein-Ligand Crystal Structures for Drug Design
- Molecular Obesity, Potency and Other Addictions in Drug Discovery
- Adventures in Small Molecule Fragment Screening by X-ray Crystallography for Drug Discovery
- Structure-Based Drug Design to Perturb Function of a tRNA-Modifying Enzyme by Active Site and Protein-Protein Interface Inhibition
- Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function.
